Cystatins: biochemical and structural properties, and medical relevance.

@article{Turk2008CystatinsBA,
  title={Cystatins: biochemical and structural properties, and medical relevance.},
  author={Vito Turk and Veronika Stoka and Du{\vs}an Turk},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2008},
  volume={13},
  pages={
          5406-20
        }
}
  • V. TurkV. StokaD. Turk
  • Published 1 May 2008
  • Biology, Chemistry
  • Frontiers in bioscience : a journal and virtual library
The cystatin superfamily comprises a large group of the cystatin domain containing proteins, present in a wide variety of organisms, including humans. Cystatin inhibitory activity is vital for the delicate regulation of normal physiological processes by limiting the potentially highly destructive activity of their target proteases such as the papain (C1) family, including cysteine cathepsins. Some of the cystatins also inhibit the legumain (C13) family of enzymes. Failures in biological… 
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