Cystatin and cystatin-derived peptides have antibacterial activity against the pathogen Porphyromonas gingivalis.

@article{Blankenvoorde1998CystatinAC,
  title={Cystatin and cystatin-derived peptides have antibacterial activity against the pathogen Porphyromonas gingivalis.},
  author={M F J Blankenvoorde and Wim van't Hof and Els Walgreen-Weterings and T J M van Steenbergen and Henk S. Brand and Enno C. I. Veerman and Arie V Nieuw Amerongen},
  journal={Biological chemistry},
  year={1998},
  volume={379 11},
  pages={1371-5}
}
We investigated whether cystatins and cystatin-derived peptides, encompassing sequences of secondary structures of cystatin S and papain binding domains of cystatin C, display antimicrobial properties. Of the different microorganisms tested, only the growth of P. gingivalis was inhibited by chicken cystatin and cystatin C. Cystatin S, cystatin S:1-14, cystatin S:61-73 and cystatin S:108-121 also inhibited its growth, whereas cystatin S:21-38, cystatin S:39-55, cystatin S:81-95, cystatin S:94… CONTINUE READING

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