Cystatin C peptidomimetic derivative with antimicrobial properties as a potential compound against wound infections.

@article{Pikua2017CystatinCP,
  title={Cystatin C peptidomimetic derivative with antimicrobial properties as a potential compound against wound infections.},
  author={Michał Pikuła and Maria Smużyńska and Adam Krzystyniak and M Zieliński and P. Therese Langa and Maria Dzierżyńska and Adriana Schumacher and Jakub Łata and Mirosława Cichorek and Anders Grubb and Piotr Trzonkowski and Franciszek Kasprzykowski and Sylwia Rodziewicz-Motowidło},
  journal={Bioorganic & medicinal chemistry},
  year={2017},
  volume={25 4},
  pages={1431-1439}
}
A peptidomimetic called A20 (Cystapep 1) structurally based upon the N-terminal fragment of human cystatin C is known to have strong antibacterial properties. A20 is characterized by high activity against several bacterial strains often isolated from infected wounds, including methicillin-resistant S. aureus (MRSA). In this work we wanted to explore the… CONTINUE READING