Cystatin C in newborns: a promising renal biomarker in search for standardization and validation.

@article{Allegaert2015CystatinCI,
  title={Cystatin C in newborns: a promising renal biomarker in search for standardization and validation.},
  author={Karel Allegaert and Djalila Mekahli and Johannes N van den Anker},
  journal={The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians},
  year={2015},
  volume={28 15},
  pages={1833-8}
}
OBJECTIVE Neonatologists still commonly use creatinine as a proxy for renal clearance, despite issues related to neonatal (patho)physiology and methodology (assay variability). Cystatin C (CysC) has been suggested to be a more reliable biomarker, but assay related differences have also been reported in children and adults. We are unaware of any review on the assay related impact on CysC reference values in newborns. METHODS A structured literature search was performed on published CysC values… CONTINUE READING

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