Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice.

@article{Sukhova2005CystatinCD,
  title={Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice.},
  author={Galina K Sukhova and Bing Wang and P. Scott Libby and J Z Pan and Yige Zhang and Anders Grubb and Kenneth C. Fang and Harold A Chapman and G P Shi},
  journal={Circulation research},
  year={2005},
  volume={96 3},
  pages={368-75}
}
The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves substantial proteolysis of the arterial extracellular matrix. The lysosomal cysteine proteases can exert potent elastolytic and collagenolytic activity. Human atherosclerotic plaques have increased cysteine protease content and decreased levels of the endogenous inhibitor cystatin C, suggesting an imbalance that would favor matrix degradation in the arterial wall. This study tested directly the hypothesis that impaired… CONTINUE READING
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