Cystatin A, a Potential Common Link for Mutant Myocilin Causative Glaucoma

@inproceedings{Kennedy2012CystatinAA,
  title={Cystatin A, a Potential Common Link for Mutant Myocilin Causative Glaucoma},
  author={Kellie Kennedy and S. A. AnithaChristy and Lakisha K Buie and Terete Borr{\'a}s},
  booktitle={PloS one},
  year={2012}
}
Myocilin (MYOC) is a 504 aa secreted glycoprotein induced by stress factors in the trabecular meshwork tissue of the eye, where it was discovered. Mutations in MYOC are linked to glaucoma. The glaucoma phenotype of each of the different MYOC mutation varies, but all of them cause elevated intraocular pressure (IOP). In cells, forty percent of wild-type MYOC is cleaved by calpain II, a cysteine protease. This proteolytic process is inhibited by MYOC mutants. In this study, we investigated the… CONTINUE READING