Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

@article{Park2009CystFI,
  title={Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.},
  author={Eun Young Park and Young Hoon Sung and Moon Hee Yang and Ji Yeun Noh and So Young Park and Tae Young Lee and Yeon Joo Yook and Kyung Yoo and Kyung Jin Roh and Ingyu Kim and Young-Hwan Hwang and Goo Taeg Oh and Je Kyung Seong and Curie Ahn and Han Woong Lee and Jong Hoon Park},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 11},
  pages={7214-22}
}
The pathogenic mechanisms of human autosomal dominant polycystic kidney disease (ADPKD) have been well known to include the mutational inactivation of PKD2. Although haploinsufficiency and loss of heterozygosity at the Pkd2 locus can cause cyst formation in mice, polycystin-2 is frequently expressed in the renal cyst of human ADPKD, raising the possibility that deregulated activation of PKD2 may be associated with the cystogenesis of human ADPKD. To determine whether increased PKD2 expression… CONTINUE READING
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