Cyprinid Herpesvirus 3 Il10 Inhibits Inflammatory Activities of Carp Macrophages and Promotes Proliferation of Igm+ B Cells and Memory T Cells in a Manner Similar to Carp Il10.

@article{Piazzon2015CyprinidH3,
  title={Cyprinid Herpesvirus 3 Il10 Inhibits Inflammatory Activities of Carp Macrophages and Promotes Proliferation of Igm+ B Cells and Memory T Cells in a Manner Similar to Carp Il10.},
  author={M Carla Piazzon and Annelieke S. Wentzel and Edwin Tijhaar and Krzysztof Rakus and Alain F C Vanderplasschen and Geert F. Wiegertjes and Maria Forlenza},
  journal={Journal of immunology},
  year={2015},
  volume={195 8},
  pages={
          3694-704
        }
}
Cyprinid herpesvirus 3 (CyHV-3) is the causative agent of a lethal disease of carp and encodes for an Il10 homolog (ORF134). Our previous studies with a recombinant ORF134-deleted strain and the derived revertant strain suggested that cyprinid herpesvirus 3 Il10 (CyHV-3 Il10 [cyhv3Il10]) is not essential for viral replication in vitro, or virulence in vivo. In apparent contrast, cyhv3Il10 is one of the most abundant proteins of the CyHV-3 secretome and is structurally very similar to carp Il10… CONTINUE READING

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