Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.

@article{Yazawa2008Cyp11b1II,
  title={Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.},
  author={Takashi Yazawa and Miki Uesaka and Yoshihiko Inaoka and Tetsuya Mizutani and Toshio Sekiguchi and Takashi Kajitani and Takeshi Kitano and Akihiro Umezawa and Kaoru Miyamoto},
  journal={Endocrinology},
  year={2008},
  volume={149 4},
  pages={1786-92}
}
We have shown previously that Cyp11b1, an 11beta-hydroxylase responsible for glucocorticoid biosynthesis in the adrenal gland, was induced by cAMP in androgen-producing Leydig-like cells derived from mesenchymal stem cells. We found that Cyp11b1 was induced in male Leydig cells, or female theca cells, when human chorionic gonadotropin was administered in… CONTINUE READING