Cyfra 21-1 as a biologic marker of non-small cell lung cancer. Evaluation of sensitivity, specificity, and prognostic role.

@article{Wieskopf1995Cyfra2A,
  title={Cyfra 21-1 as a biologic marker of non-small cell lung cancer. Evaluation of sensitivity, specificity, and prognostic role.},
  author={B Wieskopf and Christine Demangeat and Ashok Purohit and Rene Stenger and P Gries and Harvey Kreisman and Elisabeth A Quoix},
  journal={Chest},
  year={1995},
  volume={108 1},
  pages={163-9}
}
BACKGROUND Cytokeratins are epithelial markers whose expression is not lost during malignant transformation. Cyfra 21-1 is a cytokeratin-19 fragment that is soluble in serum and may be a useful circulating tumor marker. STUDY OBJECTIVE The aims of this study were (1) to confirm sensitivity and specificity of Cyfra 21-1 in detecting non-small cell lung cancer (NSCLC) and especially the squamous cell subtype, (2) to assess the potential relationship between Cyfra 21-1 and disease stage of the… CONTINUE READING
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