Cyclovirobuxine D Attenuates Doxorubicin-Induced Cardiomyopathy by Suppression of Oxidative Damage and Mitochondrial Biogenesis Impairment

@inproceedings{Guo2015CyclovirobuxineDA,
  title={Cyclovirobuxine D Attenuates Doxorubicin-Induced Cardiomyopathy by Suppression of Oxidative Damage and Mitochondrial Biogenesis Impairment},
  author={Qian Guo and Jiabin Guo and Rong Yang and Hui Peng and Jun Zhao and Li Li and Shuangqing Peng},
  booktitle={Oxidative medicine and cellular longevity},
  year={2015}
}
The clinical application of doxorubicin (DOX) is compromised by its cardiac toxic effect. Cyclovirobuxine D (CVB-D) is a steroid alkaloid extracted from a traditional Chinese medicine, Buxus microphylla. Our results showed that CVB-D pretreatment markedly attenuated DOX-induced cardiac contractile dysfunction and histological alterations. By using TUNEL assay and western blot analysis, we found that CVB-D pretreatment reduced DOX-induced apoptosis of myocardial cells and mitochondrial… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS