Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep.

@article{Colgrave2008CyclotidesNC,
  title={Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep.},
  author={Michelle L Colgrave and Andrew C. Kotze and Yen-Hua Huang and John O'Grady and Shane M Simonsen and David J. Craik},
  journal={Biochemistry},
  year={2008},
  volume={47 20},
  pages={5581-9}
}
The cyclotides are a novel family of backbone-cyclized cystine-knot containing peptides from plants that have been shown to possess insecticidal activity against Helicoverpa larvae, an important pest of corn and cotton. In the current study, we investigated the in vitro effects of the cyclotides on the viability of egg, larval, and adult life stages of two species of economically important gastrointestinal nematode parasites of livestock, Hemonchus contortus and Trichostrongylus colubriformis… CONTINUE READING
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