Cyclosporine withdrawal improves renal function in heart transplant patients on reduced-dose cyclosporine therapy.

@article{Gleissner2006CyclosporineWI,
  title={Cyclosporine withdrawal improves renal function in heart transplant patients on reduced-dose cyclosporine therapy.},
  author={Christian A. Gleissner and Andreas O. Doesch and Philipp Ehlermann and Armin Koch and F U Sack and Hugo A. Katus and Thomas J. Dengler},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2006},
  volume={6 11},
  pages={2750-8}
}
Renal failure is a major cause of morbidity after heart transplantation. It is unclear whether calcineurin inhibitor (CNI) free immunosuppression provides more nephroprotection than low-dose CNI therapy. Thirty-nine patients with renal failure on low-dose cyclosporine A (CsA) were studied (62.9 +/- 8.7 years, five female, 8.2 +/- 4.3 years posttransplant, serum creatinine: 1.9 +/- 0.3 mg/dL, calculated GFR (cGFR): 48.2 +/- 18.3 mL/min, CsA C0 level: 64.0 +/- 19.9 ng/mL). All patients had been… CONTINUE READING
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