Cyclosporine suppresses rat hepatic cytochrome P450 in a time-dependent manner.

@article{Brunner1998CyclosporineSR,
  title={Cyclosporine suppresses rat hepatic cytochrome P450 in a time-dependent manner.},
  author={L J Brunner and William M. Bennett and Dennis R. Koop},
  journal={Kidney international},
  year={1998},
  volume={54 1},
  pages={
          216-23
        }
}
BACKGROUND Cyclosporine is a potent immunosuppressant know to selectively suppress specific cytochrome P450 (P450) isoforms following chronic therapy in the rat. Cyclosporine undergoes significant hepatic metabolism in the rat, primarily due to P450 3A isoforms. Hence, alterations in hepatic metabolism of cyclosporine may lead to changes in drug pharmacokinetics or pharmacodynamics. The purpose of this study was to examine the temporal effect of chronic cyclosporine dosing on P450 protein… CONTINUE READING

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