Cyclosporine pharmacokinetics in normal and pancreatectomized dogs.

@article{White1986CyclosporinePI,
  title={Cyclosporine pharmacokinetics in normal and pancreatectomized dogs.},
  author={John Valery White and William R. Ravis and Ryan D Nachreiner and William D. Schall and Richard Walshaw and R W Bull},
  journal={Transplantation},
  year={1986},
  volume={42 4},
  pages={390-5}
}
Oral and i.v. cyclosporine (Cs) pharmacokinetics determined from radioimmunoassay (RIA) data were compared in normal and pancreatectomized dogs. An altered pharmacokinetics of Cs was observed in the pancreatectomized dogs that include: a 170% larger central compartment volume; a 34% greater total-body clearance; and lower steady-state average serum… CONTINUE READING