Cyclosporine-insensitive partial signaling and multiple roles of Ca2+ in Fas ligand-induced lysis.

@article{Rogers1997CyclosporineinsensitivePS,
  title={Cyclosporine-insensitive partial signaling and multiple roles of Ca2+ in Fas ligand-induced lysis.},
  author={Anne M. Rogers and Anja R. B. Thilenius and John H. Russell},
  journal={Journal of immunology},
  year={1997},
  volume={159 7},
  pages={3140-7}
}
The induction of Fas ligand (FasL) mRNA expression and FasL-mediated cytotoxicity in CD8+ CTL is a rapid and transient response to activation via the TCR. This response can also be initiated by pharmacologic activation of two major TCR signaling pathways using phorbol ester (PMA) and calcium ionophore (ionomycin). In these experiments using CD8+ alloreactive cell lines, we demonstrate that induction of FasL mRNA can occur in response to either PMA or ionomycin independently. However, only the… CONTINUE READING