Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells.

@article{Lim2005CyclosporineinducedRI,
  title={Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells.},
  author={Sun Woo Lim and Can Li and Kyung Ohk Ahn and Jin Oak Kim and In Sung Moon and Curie Ahn and Jeong Ryul Lee and Chul Woo Yang},
  journal={Transplantation},
  year={2005},
  volume={80 5},
  pages={691-9}
}
BACKGROUND The toll-like receptor (TLR) is stimulated by not only pathogen-associated molecular patterns but also endogenous TLR ligands provided by injured cells. The influence of cyclosporine A (CsA)-induced renal injury on TLR expression and subsequent signaling pathway was evaluated. METHODS Induction of chronic CsA nephropathy was made by administering CsA (15 mg/kg/day) for 28 days in rats. The TLR2 and TLR4 mRNA and protein expression, TLR-signaling pathway (MYD88, NF-kappaB and AP-1… CONTINUE READING

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