Cyclosporine in psoriasis treatment. Inhibition of keratinocyte cell-cycle progression in G1 independent of effects on transforming growth factor alpha/epidermal growth factor receptor pathways.

Abstract

Cyclosporine, an immunosuppressive drug, is effective in the treatment of recalcitrant psoriasis. Previous work suggested that keratinocyte hyperproliferation and inflammation are linked in psoriasis and that immune mechanisms participate in the pathogenesis of psoriasis. Transforming growth factor (TGF) alpha may be an important regulatory factor of… (More)

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@article{Khandke1991CyclosporineIP, title={Cyclosporine in psoriasis treatment. Inhibition of keratinocyte cell-cycle progression in G1 independent of effects on transforming growth factor alpha/epidermal growth factor receptor pathways.}, author={Lakshmi Khandke and Jeffrey F Krane and Russell L. Ashinoff and Lisa F Staiano-Coico and Angela Granelli-Piperno and A. D. Luster and Danielle M Carter and J. G. Krueger and A B Gottlieb}, journal={Archives of dermatology}, year={1991}, volume={127 8}, pages={1172-9} }