Cyclosporine enhances the synthesis of selected extracellular matrix proteins by renal cells "in culture". Different cell responses and phenotype characterization.

@article{Ghiggeri1994CyclosporineET,
  title={Cyclosporine enhances the synthesis of selected extracellular matrix proteins by renal cells "in culture". Different cell responses and phenotype characterization.},
  author={Gian Marco Ghiggeri and Paola Altieri and Roberta Oleggini and Fulvia Valenti and Fabrizio Ginevri and Francesco Perfumo and Rosanna G. Gusmano},
  journal={Transplantation},
  year={1994},
  volume={57 9},
  pages={1382-8}
}
Glomerulosclerosis and interstitial fibrosis are 2 major side effects of protracted therapy with CsA in heart transplant patients and in nonrenal immunologic diseases. To investigate whether there is any cause-effect correlation between CsA and the synthesis of extracellular matrix in the kidney, we determined the amount and composition of collagens produced by various renal cells "in culture" upon exposure to increasing levels of CsA. The cellular models we used included primary cultures of… CONTINUE READING

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