Cyclosporine concentration-dependent increase in concentration ratio of mycophenolic acid acyl and phenol glucuronides to mycophenolic acid in stable kidney transplant recipients.

Abstract

OBJECTIVES The aim of this study was to evaluate the influence of cyclosporine (CyA) and tacrolimus (Tac) on the pharmacokinetics of mycophenolic acid (MPA) and its glucuronides. DESIGN AND METHODS Kidney transplant recipients treated with mycophenolate mofetil and CyA (n=18) or Tac (n=17) in the stable phase were enrolled. The dependence of the trough… (More)
DOI: 10.1016/j.clinbiochem.2008.11.013

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@article{Mino2009CyclosporineCI, title={Cyclosporine concentration-dependent increase in concentration ratio of mycophenolic acid acyl and phenol glucuronides to mycophenolic acid in stable kidney transplant recipients.}, author={Yasuaki Mino and Takafumi Naito and Atsushi Otsuka and Tomomi Ushiyama and Seiichiro Ozono and Yoshiyuki Kagawa and Junichi Kawakami}, journal={Clinical biochemistry}, year={2009}, volume={42 7-8}, pages={595-601} }