Cyclosporine blocks incorporation of HIV-1 envelope glycoprotein into virions.

@article{Sokolskaja2010CyclosporineBI,
  title={Cyclosporine blocks incorporation of HIV-1 envelope glycoprotein into virions.},
  author={Elena Sokolskaja and Silvia Olivari and Madeleine Zufferey and Caterina Strambio-De-Castillia and Massimo Pizzato and Jeremy Luban},
  journal={Journal of virology},
  year={2010},
  volume={84 9},
  pages={
          4851-5
        }
}
Cyclosporine (CsA) decreases HIV-1 infectivity by blocking HIV-1 capsid (CA) interaction with target cell cyclophilin A (CypA). Yet, HIV-1 virions produced in the presence of CsA also exhibit decreased infectivity that was previously shown to be independent of the well-characterized HIV-1 CA-CypA interaction. Here, we demonstrate that CsA decreases gp120 and gp41 incorporation into HIV-1 virions and that the fusion of these virions with susceptible target cells is impaired. This effect was not… CONTINUE READING

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