Cyclosporine and Herbal Supplement Interactions

@inproceedings{Colombo2014CyclosporineAH,
  title={Cyclosporine and Herbal Supplement Interactions},
  author={Delia Colombo and Luisa Lunardon and Gilberto Bellia},
  booktitle={Journal of toxicology},
  year={2014}
}
Cyclosporine (CyA) is a well-known immunosuppressant with a narrow therapeutic window. Its bioavailability is affected by many other traditional drugs and herbal extracts. Cytochrome P-450 isoenzymes CYP3A4 and CYP3A5 and protein P-glycoprotein (P-gp) are involved in CyA bioavailability. Interactions of CyA with herbal extracts are not well known, but, given their increased concomitant use, it is important to know which extracts, many of which are commonly self-prescribed, can affect CyA blood… CONTINUE READING

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Principles of pharmacological research of nutraceuticals

  • British journal of pharmacology
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Ginger significantly decreased the oral bioavailability of cyclosporine in rats.

  • The American journal of Chinese medicine
  • 2006
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures.

  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2000
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL