Cyclosporine A suppresses keratinocyte cell death through MPTP inhibition in a model for skin cancer in organ transplant recipients.

@article{Norman2010CyclosporineAS,
  title={Cyclosporine A suppresses keratinocyte cell death through MPTP inhibition in a model for skin cancer in organ transplant recipients.},
  author={Kimberly G Norman and Jeffrey A. Canter and Mingjian Shi and Ginger L Milne and Jason D. Morrow and James E. Sligh},
  journal={Mitochondrion},
  year={2010},
  volume={10 2},
  pages={94-101}
}
Transplant recipients have an elevated risk of skin cancer, with a 65- to 250-fold increase in squamous cell carcinoma. Usage of the immunosuppressant cyclosporine A (CsA) is associated with the development of skin cancer. We hypothesized that the increased incidence of skin cancer was due to the action of CsA within keratinocyte mitochondria where it can inhibit mitochondrial permeability transition pore (MPTP) opening. Normally, MPTP opening is induced by oxidative stress such as that caused… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Cyclophilin D-dependent

  • T. Nakagawa, S. Shimizu, +6 authors Y. Tsujimoto
  • 2005
Highly Influential
6 Excerpts

) 94 – 101 101 mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

  • I. Penn
  • Nature
  • 2010

Similar Papers

Loading similar papers…