Cyclosporine A prevents vascular hyperpermeability after hemorrhagic shock by inhibiting apoptotic signaling.

@article{Tharakan2009CyclosporineAP,
  title={Cyclosporine A prevents vascular hyperpermeability after hemorrhagic shock by inhibiting apoptotic signaling.},
  author={B. D. Tharakan and Juliet G. Holder-Haynes and Felicia A. Hunter and William Roy Smythe and Ed W. Childs},
  journal={The Journal of trauma},
  year={2009},
  volume={66 4},
  pages={
          1033-9
        }
}
BACKGROUND Hemorrhagic shock (HS) is associated with the activation of caspase-dependent or -independent apoptotic signaling pathways, disruption of endothelial cell adherens junctions, and vascular hyperpermeability. Recent studies have suggested that the vascular hyperpermeability observed after HS is associated with activation of the intrinsic apoptotic signaling cascade resulting in caspase-mediated cleavage of endothelial cell adherens proteins and subsequent cell-cell detachment. We… CONTINUE READING
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