Cyclosporine A loaded SLNs: evaluation of cellular uptake and corneal cytotoxicity.

Abstract

Cyclosporine A (CsA) loaded solid lipid nanoparticles (SLNs) for topical ophthalmic applications were prepared by high shear homogenization and ultrasound method using Compritol 888 ATO, Poloxamer 188 and Tween 80, to investigate the cellular uptake of rabbit corneal epithelial cells (RCE) and to evaluate the cytotoxicity. The size of the optimized… (More)
DOI: 10.1016/j.ijpharm.2008.07.028

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