Cyclosporine A-induced prostacyclin release is maintained by extracellular calcium in rat aortic endothelial cells: role of protein kinase C.

@article{Oriji1999CyclosporineAP,
  title={Cyclosporine A-induced prostacyclin release is maintained by extracellular calcium in rat aortic endothelial cells: role of protein kinase C.},
  author={Gibson K Oriji},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={1999},
  volume={61 2},
  pages={119-23}
}
  • Gibson K Oriji
  • Published 1999 in
    Prostaglandins, leukotrienes, and essential fatty…
Chronic treatment with the immunosuppressive drug Cyclosporine A (CsA) is associated with increased intracellular calcium in vascular smooth muscle cells, which may activate phospholipase A2. We used rat aortic endothelial cells to investigate the role of protein kinase C (PKC) in CsA-induced prostacyclin (PGI2) release. CsA (10(-9) M) produced a… CONTINUE READING