Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro.

@article{Amundsen2012CyclosporineAA,
  title={Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro.},
  author={Rune Amundsen and Anders {\AA}sberg and Ingrid Kristine Ohm and Hege Christensen},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2012},
  volume={40 4},
  pages={655-61}
}
Cyclosporine A (CsA) and tacrolimus (Tac) are immunosuppressive drugs used in the majority of patients with solid organ transplants, generally in combination with a wide range of drugs. CsA and Tac seem not only to be substrates of CYP3A but have also been described as inhibitors of CYP3A. For CsA, in particular, inhibition of CYP3A has been suggested as the main mechanism of interactions seen clinically with various drugs. The aim of this study was to investigate the inhibitory effect and… CONTINUE READING

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Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Cyclosporine A- and tacrolimus - mediated inhibition of CYP3A4 and CYP3A5 in vitro . Cyclosporine A ( CsA ) and tacrolimus ( Tac )
Inhibition by CsA and Tac was studied using midazolam as the probe substrate in coincubation and preincubation investigations using human liver microsomes ( HLMs ) as well as specific CYP3A4- and CYP3A5-expressing insect microsomes ( Supersomes ) .
Inhibition by CsA and Tac was studied using midazolam as the probe substrate in coincubation and preincubation investigations using human liver microsomes ( HLMs ) as well as specific CYP3A4- and CYP3A5-expressing insect microsomes ( Supersomes ) .
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