Cyclosporine A Impairs Nucleotide Binding Oligomerization Domain (Nod1)-Mediated Innate Antibacterial Renal Defenses in Mice and Human Transplant Recipients

@inproceedings{Tourneur2013CyclosporineAI,
  title={Cyclosporine A Impairs Nucleotide Binding Oligomerization Domain (Nod1)-Mediated Innate Antibacterial Renal Defenses in Mice and Human Transplant Recipients},
  author={Emilie Tourneur and Sanae Ben Mkaddem and C{\'e}cilia Chassin and Marcelle Bens and J M Goujon and Nicolas Charles and Christophe Pellefigues and Meryem Aloulou and Alexandre Hertig and Renato C Monteiro and Stephen E. Girardin and Dana J Philpott and Eric Rondeau and Carole Elbim and Catherine Werts and Alain Vandewalle},
  booktitle={PLoS pathogens},
  year={2013}
}
Acute pyelonephritis (APN), which is mainly caused by uropathogenic Escherichia coli (UPEC), is the most common bacterial complication in renal transplant recipients receiving immunosuppressive treatment. However, it remains unclear how immunosuppressive drugs, such as the calcineurin inhibitor cyclosporine A (CsA), decrease renal resistance to UPEC. Here, we investigated the effects of CsA in host defense against UPEC in an experimental model of APN. We show that CsA-treated mice exhibit… CONTINUE READING
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