Cyclosporine-A, but not tacrolimus significantly increases reactivity of vascular smooth muscle cells.

@article{Grzek2016CyclosporineABN,
  title={Cyclosporine-A, but not tacrolimus significantly increases reactivity of vascular smooth muscle cells.},
  author={Elżbieta Grześk and Bartosz Malinowski and Michał Wiciński and Katarzyna Szadujkis-Szadurska and Thabit A Sinjab and Sławomir Manysiak and Barbara Tejza and Maciej Słupski and Grażyna Odrowąż-Sypniewska and Grzegorz Grześk},
  journal={Pharmacological reports : PR},
  year={2016},
  volume={68 1},
  pages={201-5}
}
BACKGROUND Application of cyclosporine-A (CsA) or tacrolimus is associated with numerous side effects. One of the main reasons for restricting usage of CsA is hypertension. In tacrolimus treated subjects the frequency of these phenomena is significantly lower. The known molecular mechanism of action of tacrolimus and cyclosporine-A seems to be the same, thus we decided to compare modulatory effect of drugs on vascular smooth muscle contractility. METHODS Experiments were performed on isolated… CONTINUE READING