Cyclosporine: Immunology, toxicity and pharmacology in experimental animals

@article{Thomson1984CyclosporineIT,
  title={Cyclosporine: Immunology, toxicity and pharmacology in experimental animals},
  author={Angus W Thomson and Paul H. Whiting and John G. Simpson},
  journal={Agents and Actions},
  year={1984},
  volume={15},
  pages={306-327}
}
Cyclosporine (CsA) is the first of a new order of pharmacological immune suppressants and represents a significant advance in the clinical control of graft rejection. In laboratory animals, its capacity to prolong allograft survival has been well documented, including reports of indefinite donor-specific immunological tolerance after shortterm CsA treatment. There is also evidence that CsA can inhibit the onset or progress of a variety of experimental autoimmune diseases. Underlying these… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 107 REFERENCES

TURK, Kinetics of the effect of a single dose of cyclosporin A on antibody and cell-mediated immune responses in the guinea pig

  • J.L
  • Int. J. Immunopharmac
  • 1984

The enhancement of cyelosporin Ainduced nephrotoxicity by gentamicin

  • J. G. SIMPSON
  • Biochem . Pharmac .
  • 1984

BENZlE, Effects ofcyclosporin A on the metabolism of unstimulated and mitogenactivated lymphocytes, Immunology

  • KAY C.R.J.E
  • 1983

Cyclosporin A and lymphokines affecting macrophage behaviour

  • D. K. MOON, C. L. GECZY, D. S. NELSON
  • Transplant . Proc .
  • 1983

Cyclosporin A and lymphokines affecting macrophage behaviour, Transplant

  • A. W. THOMSON, D. K. MOON, C. L. GECZV, D. S. NELSON
  • Proc. 15,
  • 1983

Cyclosporin A: mechanism of action, Transplant

  • H. WAGNER
  • Proc. 15,
  • 1983