Cyclosporine: A Commentary on Brand versus Generic Formulation Exchange

  title={Cyclosporine: A Commentary on Brand versus Generic Formulation Exchange},
  author={Anurag Singh and Sriram S. Narsipur},
  booktitle={Journal of transplantation},
The evidence for conversion from brand name to generic equivalent cyclosporine is conflicting. Cyclosporine is a narrow therapeutic-range drug for which small variations in exposure may have severe clinical consequences for transplant patients. There is currently a lack of comparative outcome data relating to the pharmacokinetics of the reference formulation, Neoral, and generic formulations in transplant recipients. A major common concern is the potential inability to attain similar trough… CONTINUE READING