Cyclosporin trough levels: is monitoring necessary during short-term treatment in psoriasis? A systematic review and clinical data on trough levels.

@article{Heydendael2002CyclosporinTL,
  title={Cyclosporin trough levels: is monitoring necessary during short-term treatment in psoriasis? A systematic review and clinical data on trough levels.},
  author={Vera M. R. Heydendael and P I Spuls and Ineke R J M Ten Berge and Brent C. Opmeer and Jan Dositheus Bos and Menno A. de Rie},
  journal={The British journal of dermatology},
  year={2002},
  volume={147 1},
  pages={122-9}
}
BACKGROUND Cyclosporin is an effective treatment for severe plaque psoriasis. Unfortunately, its use may be limited by time- and dose-related nephrotoxicity. Serum trough levels may be useful for monitoring the risk of nephrotoxicity. OBJECTIVES To determine whether monitoring of trough levels is necessary in psoriasis patients undergoing short-term treatment with cyclosporin. METHODS A computerized and manual literature search identified studies on adults with plaque-type psoriasis treated… CONTINUE READING