Cyclosporin therapy in patients with Alport syndrome

  title={Cyclosporin therapy in patients with Alport syndrome},
  author={Marina Charbit and M K Gubler and Mich{\`e}le D{\'e}chaux and M E Gagnadoux and J. -P. Gr{\"u}nfeld and Patrick Niaudet},
  journal={Pediatric Nephrology},
Alport syndrome (AS) is a hereditary disorder of type IV collagen characterized by the association of progressive hematuric nephritis and sensorineural hearing loss. An increase in proteinuria is linked with progressive renal failure. Preliminary data have shown that cyclosporin therapy reduces proteinuria, thereby suggesting that it may also slow the progression of AS nephropathy. We treated nine AS patients manifesting proteinuria >1 g/m2/day and a glomerular filtration rate (GFR) >50 ml/min… CONTINUE READING


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