Cyclosporin-induced renal vasoconstriction is augmented by frusemide and by angiotensin II in humans.

@article{Sturrock1995CyclosporininducedRV,
  title={Cyclosporin-induced renal vasoconstriction is augmented by frusemide and by angiotensin II in humans.},
  author={N D Sturrock and Chim C Lang and Wendy J. R. Coutie and Allan D. Struthers},
  journal={Journal of hypertension},
  year={1995},
  volume={13 9},
  pages={987-91}
}
OBJECTIVE To investigate the role of the renin-angiotensin-aldosterone system as a homoeostatic mechanism by examining whether mild activation of the renin-angiotensin-aldosterone system could enhance cyclosporin-induced renal vasoconstriction and hypertension. METHODS We artificially activated the renin-angiotensin-aldosterone system by two means: by pretreatment with frusemide (40 mg/day orally for 2 days) and by administering exogenous angiotensin II (1 ng/kg per min intravenously). In… CONTINUE READING