Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices.

@article{Erxleben2006CyclosporinAT,
  title={Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices.},
  author={Christian F Erxleben and Yanhong Liao and Saverio Gentile and David C. W. Chin and Claudio Jaime Gomez-Alegria and Yasuo Mori and Lutz Birnbaumer and David Lee Armstrong},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 10},
  pages={3932-7}
}
Calcium channels in the plasma membrane rarely remain open for much more than a millisecond at any one time, which avoids raising intracellular calcium to toxic levels. However, the dihydropyridine-sensitive calcium channels of the CaV1 family, which selectively couple electrical excitation to endocrine secretion, cardiovascular contractility, and neuronal transcription, have a unique second mode of gating, "mode 2," that involves frequent openings of much longer duration. Here we report that… CONTINUE READING