Cyclosporin A treatment alters characteristics of Ca2+-release channel in cardiac sarcoplasmic reticulum.

@article{Park1999CyclosporinAT,
  title={Cyclosporin A treatment alters characteristics of Ca2+-release channel in cardiac sarcoplasmic reticulum.},
  author={Kyoung Sik Park and Tae Kon Kim and Do Han Kim},
  journal={The American journal of physiology},
  year={1999},
  volume={276 3 Pt 2},
  pages={H865-72}
}
Chronic treatment with cyclosporin A (CsA) has been reported (H. S. Banijamali, M. H. ter Keurs, L. C. Paul, and H. E. ter Keurs. Cardiovasc. Res. 27: 1845-1854, 1993; I. Kingma, E. Harmsen, H. E. ter Keurs, H. Benediktsson, and L. C. Paul. Int. J. Cardiol. 31: 15-22, 1991) to induce reversible alterations of contractile properties in rat hearts. To define the molecular mechanisms underlying the physiological alterations, the Ca2+-release channel (CRC) and Ca2+-ATPase from sarcoplasmic… CONTINUE READING

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