Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats.

@article{Colombo1994CyclosporinAM,
  title={Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats.},
  author={Tina Colombo and Massimo Zucchetti and Maurizio D'Incalci},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={269 1},
  pages={22-7}
}
Cyclosporin A (CsA) inhibits the membrane transport protein Pgp and can thus restore sensitivity to doxorubicin (Dx) and other antineoplastic agents in multidrug resistant cancer cells. Because Pgp is not expressed only in resistant tumor cells but also in normal tissues, CsA may modify the distribution of a concomitantly given antitumor agent which is a… CONTINUE READING