Cyclosporin A inhibits the release of histamine and peptide leukotriene C4 from human lung mast cells.

@article{Marone1988CyclosporinAI,
  title={Cyclosporin A inhibits the release of histamine and peptide leukotriene C4 from human lung mast cells.},
  author={Gianni Marone and Massimo Triggiani and Rocco Cirillo and A. Giacummo and L Siri and Mario Condorelli},
  journal={La Ricerca in clinica e in laboratorio},
  year={1988},
  volume={18 1},
  pages={53-9}
}
We investigated the effect of cyclosporin A (CsA) on in vitro release of chemical mediators from mast cells purified from human lung tissues. CsA (3 X 10(-2) to 1 microgram/ml) dose-dependently inhibited IgE-mediated release of histamine and peptide leukotriene C4 (LTC4) from human lung mast cells. The same concentrations of CsA also inhibited the release… CONTINUE READING