Cyclosporin A inhibits prostaglandin E2 formation by rat mesangial cells in culture.

@article{Stahl1989CyclosporinAI,
  title={Cyclosporin A inhibits prostaglandin E2 formation by rat mesangial cells in culture.},
  author={R. A. K. Stahl and Stephen J. Adler and Patricia J. Baker and Richard J Johnson and Y P Chen and P M Pritzl and William G. Couser},
  journal={Kidney international},
  year={1989},
  volume={35 5},
  pages={1161-7}
}
A reversible reduction in glomerular filtration rate (GFR) is a frequent side effect in patients treated with the immunosuppressant cyclosporin A (CsA). The pathophysiology of acute CsA nephrotoxicity, however, is unclear. Since eicosanoids are local mediators of glomerular hemodynamics, they might be involved in CsA induced changes in GFR. We therefore studied the effect of CsA on prostaglandin E2 (PGE2) production by rat mesangial cells in culture. PGE2 production by mesangial cells following… CONTINUE READING

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