Cyclosporin A induces the opening of a potassium-selective channel in higher plant mitochondria.

@article{Petrussa2001CyclosporinAI,
  title={Cyclosporin A induces the opening of a potassium-selective channel in higher plant mitochondria.},
  author={E Petrussa and V Casolo and Enrico Braidot and Elisa Chiandussi and Francesco Macr{\`i} and A Vianello},
  journal={Journal of bioenergetics and biomembranes},
  year={2001},
  volume={33 2},
  pages={107-17}
}
The immunosuppressive drug, cyclosporin A (CsA), induces the generation of a transmembrane electrical potential difference (deltapsi) in deenergized plant mitochondria incubated in sucrose-based media. Build up of deltapsi is prevented by external monovalent cations in the order K+ > Rb+ = Li+ > Na+, or by the protonophore carbonyl cyanide p… CONTINUE READING