Cyclosporin A improves brain tissue oxygen consumption and learning/memory performance after lateral fluid percussion injury in rats.

@article{Alessandri2002CyclosporinAI,
  title={Cyclosporin A improves brain tissue oxygen consumption and learning/memory performance after lateral fluid percussion injury in rats.},
  author={Beat Alessandri and Ann C. Rice and Joseph E Levasseur and Michelle S Deford and Robert J Hamm and Malcolm Ross Bullock},
  journal={Journal of neurotrauma},
  year={2002},
  volume={19 7},
  pages={829-41}
}
Traumatic brain injury (TBI) triggers a complex pathophysiological cascade, leading to cell death. A major factor in the pathogenesis of TBI is neuronal overloading with calcium, causing the opening of mitochondrial permeability transition pores (MPTP), which consequently inhibit normal mitochondrial function. The immunosuppressant Cyclosporin A (CsA) has been shown to block MPTPs, and to be neuroprotective in ischemia and TBI. However, the translation of these effects on mitochondrial function… CONTINUE READING