Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling

@article{Rafiee2004CyclosporinAD,
  title={Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling},
  author={P Mohammad Rafiee and Jan Heidemann and Hitoshi Ogawa and Nathan A. Johnson and Pamela Jane Fisher and Mona S. Li and Mary Francis Otterson and Christopher Peter Johnson and David G. Binion},
  journal={Cell communication and signaling : CCS},
  year={2004},
  volume={2},
  pages={3 - 3}
}
The immunosuppressive agent cyclosporin A (CsA), a calcineurin inhibitor which blocks T cell activation has provided the pharmacologic foundation for organ transplantation. CsA exerts additional effects on non-immune cell populations and may adversely effect microvascular endothelial cells, contributing to chronic rejection, a long-term clinical complication and significant cause of mortality in solid-organ transplants, including patients with small bowel allografts. Growth of new blood vessels… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

Vascular Endothelial Growth Factor Activates Nuclear Factor of Activated T-Cells in Human Endothelial Cells: a Role for Tissue Factor Gene Expression

  • AL Armesilla, E Lorenzo, P Gomez del Arco, S Martinez-Martinez, A Alfranca, JM Redondo
  • Mol Cell Biol
  • 1999
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…