Cyclosporin A binding to calmodulin: a possible site of action on T lymphocytes.

@article{Colombani1985CyclosporinAB,
  title={Cyclosporin A binding to calmodulin: a possible site of action on T lymphocytes.},
  author={Paul M. Colombani and Anja Robb and Ann Hess},
  journal={Science},
  year={1985},
  volume={228 4697},
  pages={337-9}
}
Cyclosporin A, a potent immunosuppressive agent, has been widely used to treat patients with solid organ transplants. Although its precise mechanism of action is unknown, it appears to inhibit subsets of T lymphocytes at an early stage in cell activation. Fluorescent, fully active derivatives of cyclosporin A and calmodulin, a protein that binds calcium and… CONTINUE READING