Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury.

@article{Sullivan1999CyclosporinAA,
  title={Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury.},
  author={Patrick G. Sullivan and Morrow B. Thompson and Stephen William Scheff},
  journal={Experimental neurology},
  year={1999},
  volume={160 1},
  pages={226-34}
}
Experimental traumatic brain injury (TBI) results in a rapid and significant necrosis of cortical tissue at the site of injury. In the ensuring hours and days, secondary injury exacerbates the primary damage, resulting in significant neurological dysfunction. Recent reports from our lab and others have demonstrated that the immunosuppressant cyclosporin A (CsA) is neuroprotective following TBI. The opening of the mitochondrial permeability transition pore (MPTP) is inhibited by CsA, thereby… CONTINUE READING
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