Cyclosporin A affects red blood cell deformability in vivo but not in vitro in guinea pig.

@article{Baskurt1995CyclosporinAA,
  title={Cyclosporin A affects red blood cell deformability in vivo but not in vitro in guinea pig.},
  author={Oguz K. Baskurt and Umit Kemal Sent{\"u}rk and N Dayan and Vural K{\"u}ç{\"u}katay and M Isbir and Ahmet Erkiliç and I Kaputlu},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={274 3},
  pages={1438-42}
}
A hemorheological mechanism has been proposed for the hemodynamic effects of cyclosporin A (CsA). In vivo and in vitro effects of CsA on red blood cell (RBC) deformability were investigated in guinea pigs. RBC transit time, measured by a cell transit analyzer, was found to be prolonged, implying impaired deformability in guinea pigs treated with CsA (10 mg… CONTINUE READING