Cyclosporin-A Inhibits Constitutive Nitric Oxide Synthase Activity and Neuronal and Endothelial Nitric Oxide Synthase Expressions after Spinal Cord Injury in Rats

@article{DazRuz2005CyclosporinAIC,
  title={Cyclosporin-A Inhibits Constitutive Nitric Oxide Synthase Activity and Neuronal and Endothelial Nitric Oxide Synthase Expressions after Spinal Cord Injury in Rats},
  author={Araceli D{\'i}az-Ru{\'i}z and Paula Vergara and Francisca P{\'e}rez-Severiano and Jos{\'e} Segovia and Gabriel Gu{\'i}zar-Sahag{\'u}n and Antonio Ibarra and Camilo R{\'i}os},
  journal={Neurochemical Research},
  year={2005},
  volume={30},
  pages={245-251}
}
Nitric oxide (NO) plays a role in the pathophysiology of spinal cord injury (SCI). NO is produced by three types of nitric oxide synthase (NOS) enzymes: The constitutive Ca2+/calmodulin-dependent neuronal NOS (nNOS) and endothelial NOS (eNOS) isoforms, and the inducible calcium-independent isoform (iNOS). During the early stages of SCI, nNOS and eNOS produce significant amounts of NO, therefore, the regulation of their activity and expression may participate in the damage after SCI. In the… CONTINUE READING

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