Cyclosphosphamide therapy of medulloblastoma: From the laboratory to the clinic and back again (and again and again)

Abstract

Medulloblastoma, the most common malignancy of childhood, was originally shown to be sensitive to cyclophosphamide in 1981. We have used combined laboratory and clinical investigations to demonstrate the synergy of cyclophosphamide and vincristine in the treatment of this tumor, the therapeutic gain associated with escalation of the dosage of… (More)
DOI: 10.1007/BF01052667

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