Cyclopropyl Carboxamides, a Chemically Novel Class of Antimalarial Agents Identified in a Phenotypic Screen

  title={Cyclopropyl Carboxamides, a Chemically Novel Class of Antimalarial Agents Identified in a Phenotypic Screen},
  author={Laura M Sanz and Mar{\'i}a Bel{\'e}n Jim{\'e}nez-D{\'i}az and Benigno Crespo and Cristina De-C{\'o}zar and Mar{\'i}a Jes{\'u}s Almela and I{\~n}igo Angulo-Barturen and Pablo Casta{\~n}eda and Javier Ib{\'a}{\~n}ez and Esther Fern{\'a}ndez and Santiago Ferrer and Esperanza Herreros and Sonia Lozano and Mar{\'i}a Santos Mart{\'i}nez and Lourdes Rueda and Jeremy N. Burrows and Jose F. Garc{\'i}a-Bustos and Francisco Javier Gamo},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={5740 - 5745}
ABSTRACT Malaria is one of the deadliest infectious diseases in the world, with the eukaryotic parasite Plasmodium falciparum causing the most severe form of the disease. Discovery of new classes of antimalarial drugs has become an urgent task to counteract the increasing problem of drug resistance. Screening directly for compounds able to inhibit parasite growth in vitro is one of the main approaches the malaria research community is now pursuing for the identification of novel antimalarial… 

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Variations in frequencies of drug resistance in Plasmodium falciparum.

  • P. RathodT. McErleanP. Lee
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    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
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