Cyclopropenium Nanoparticles and Gene Transfection in Cells

  title={Cyclopropenium Nanoparticles and Gene Transfection in Cells},
  author={Noam Y. Steinman and Luis M. Campos and Yakai Feng and Abraham J. Domb and Hossein Hosseinkhani},
Non-viral vectors for the transfection of genetic material are at the frontier of medical science. In this article, we introduce for the first time, cyclopropenium-containing nanoparticles as a cationic carrier for gene transfection, as an alternative to the common quaternary ammonium transfection agents. Cyclopropenium-based cationic nanoparticles were prepared by crosslinking poly(ethylene imine) (PEI) with tetrachlorocyclopropene. These nanoparticles were electrostatically complexed with… 
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