Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase.

Abstract

Cyclopropavir (CPV) is active against human cytomegalovirus (CMV), as well as both variants of human herpesvirus 6 and human herpesvirus 8. The mechanism of action of CPV against CMV is similar to that of ganciclovir (GCV) in that it is phosphorylated initially by the CMV UL97 kinase, resulting in inhibition of viral DNA synthesis. Resistance to CPV maps to… (More)
DOI: 10.1128/AAC.00571-11

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